MovDisordV3, Main, Exploration, bibRecord, 000344

A population-based study on combined markers for early Parkinson's disease.

Identifieur interne : 000344 ( Main/Exploration ); précédent : 000343; suivant : 000345

A population-based study on combined markers for early Parkinson's disease.

Auteurs : Sinem Tunc [Allemagne] ; Julia Graf ; Vera Tadic ; Norbert Brüggemann ; Alexander Schmidt ; Mohamed Al-Khaled ; Simone Wolff ; Eva-Juliane Vollstedt ; Anne Lorwin ; Jennie Hampf ; Linda Piskol ; Christine Klein ; Johann Hagenah ; Meike Kasten

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25546094

Abstract

The prerequisite for an earlier diagnosis of Parkinson's disease (PD) are markers that are both sensitive and specific for clinically definite PD and its prediagnosic phases. Promising candidates include enlarged hyperechogenicity of the substantia nigra (SN+) on transcranial sonography (TCS) and hyposmia. However, despite good sensitivity and specificity, both markers have yet failed to yield reliable predictions. We pursue the possibility of combined use in an ongoing population-based cohort. Subjects were recruited from 10,000 inhabitants of Luebeck/Germany aged 50 to 79 years and additional PD patients from our outpatient clinic. After neurological examination, 715 subjects were grouped into clinically definite PD (n = 106), possible prediagnostic PD (ppPD; n = 73), and a control group subdivided into healthy individuals (n = 283) and controls with diseases other than PD (n = 253). Subjects underwent TCS and smell testing. Sensitivity and specificity of SN+ and hyposmia were good for PD; however, positive predictive values (PPV) of both SN+ (5.2%) and olfaction (2.5%) were low. At least one positive/both positive markers were present in 33%/1% of healthy controls, 33%/2% of diseased controls, 62%/7% of ppPD, and 94%/51% of PD. When combining SN+ and hyposmia, PPV increased to 17.6%, with a sensitivity of 51% and a specificity of 98%. Both SN+ and hyposmia offer good enrichment towards PD and ppPD, are stable against other diseases, and the combination of markers highly increases specificity. However, if the combination of SN+ and hyposmia were used as criterion for PD diagnosis, almost half of clinically definite PD and more than 90% of ppPD would have been missed.

DOI: 10.1002/mds.26100
PubMed: 25546094

Affiliations:

Allemagne

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A population-based study on combined markers for early Parkinson's disease.</title>
<author><name sortKey="Tunc, Sinem" sort="Tunc, Sinem" uniqKey="Tunc S" first="Sinem" last="Tunc">Sinem Tunc</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Luebeck, Germany; Institute of Neurogenetics, University of Luebeck, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Luebeck, Germany; Institute of Neurogenetics, University of Luebeck</wicri:regionArea>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Graf, Julia" sort="Graf, Julia" uniqKey="Graf J" first="Julia" last="Graf">Julia Graf</name>
</author>
<author><name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name>
</author>
<author><name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name>
</author>
<author><name sortKey="Schmidt, Alexander" sort="Schmidt, Alexander" uniqKey="Schmidt A" first="Alexander" last="Schmidt">Alexander Schmidt</name>
</author>
<author><name sortKey="Al Khaled, Mohamed" sort="Al Khaled, Mohamed" uniqKey="Al Khaled M" first="Mohamed" last="Al-Khaled">Mohamed Al-Khaled</name>
</author>
<author><name sortKey="Wolff, Simone" sort="Wolff, Simone" uniqKey="Wolff S" first="Simone" last="Wolff">Simone Wolff</name>
</author>
<author><name sortKey="Vollstedt, Eva Juliane" sort="Vollstedt, Eva Juliane" uniqKey="Vollstedt E" first="Eva-Juliane" last="Vollstedt">Eva-Juliane Vollstedt</name>
</author>
<author><name sortKey="Lorwin, Anne" sort="Lorwin, Anne" uniqKey="Lorwin A" first="Anne" last="Lorwin">Anne Lorwin</name>
</author>
<author><name sortKey="Hampf, Jennie" sort="Hampf, Jennie" uniqKey="Hampf J" first="Jennie" last="Hampf">Jennie Hampf</name>
</author>
<author><name sortKey="Piskol, Linda" sort="Piskol, Linda" uniqKey="Piskol L" first="Linda" last="Piskol">Linda Piskol</name>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
</author>
<author><name sortKey="Hagenah, Johann" sort="Hagenah, Johann" uniqKey="Hagenah J" first="Johann" last="Hagenah">Johann Hagenah</name>
</author>
<author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25546094</idno>
<idno type="pmid">25546094</idno>
<idno type="doi">10.1002/mds.26100</idno>
<idno type="wicri:Area/PubMed/Corpus">000299</idno>
<idno type="wicri:Area/PubMed/Curation">000299</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000345</idno>
<idno type="wicri:Area/Ncbi/Merge">004210</idno>
<idno type="wicri:Area/Ncbi/Curation">004210</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004210</idno>
<idno type="wicri:Area/Main/Merge">000344</idno>
<idno type="wicri:Area/Main/Curation">000344</idno>
<idno type="wicri:Area/Main/Exploration">000344</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A population-based study on combined markers for early Parkinson's disease.</title>
<author><name sortKey="Tunc, Sinem" sort="Tunc, Sinem" uniqKey="Tunc S" first="Sinem" last="Tunc">Sinem Tunc</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Luebeck, Germany; Institute of Neurogenetics, University of Luebeck, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Luebeck, Germany; Institute of Neurogenetics, University of Luebeck</wicri:regionArea>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Graf, Julia" sort="Graf, Julia" uniqKey="Graf J" first="Julia" last="Graf">Julia Graf</name>
</author>
<author><name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name>
</author>
<author><name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name>
</author>
<author><name sortKey="Schmidt, Alexander" sort="Schmidt, Alexander" uniqKey="Schmidt A" first="Alexander" last="Schmidt">Alexander Schmidt</name>
</author>
<author><name sortKey="Al Khaled, Mohamed" sort="Al Khaled, Mohamed" uniqKey="Al Khaled M" first="Mohamed" last="Al-Khaled">Mohamed Al-Khaled</name>
</author>
<author><name sortKey="Wolff, Simone" sort="Wolff, Simone" uniqKey="Wolff S" first="Simone" last="Wolff">Simone Wolff</name>
</author>
<author><name sortKey="Vollstedt, Eva Juliane" sort="Vollstedt, Eva Juliane" uniqKey="Vollstedt E" first="Eva-Juliane" last="Vollstedt">Eva-Juliane Vollstedt</name>
</author>
<author><name sortKey="Lorwin, Anne" sort="Lorwin, Anne" uniqKey="Lorwin A" first="Anne" last="Lorwin">Anne Lorwin</name>
</author>
<author><name sortKey="Hampf, Jennie" sort="Hampf, Jennie" uniqKey="Hampf J" first="Jennie" last="Hampf">Jennie Hampf</name>
</author>
<author><name sortKey="Piskol, Linda" sort="Piskol, Linda" uniqKey="Piskol L" first="Linda" last="Piskol">Linda Piskol</name>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
</author>
<author><name sortKey="Hagenah, Johann" sort="Hagenah, Johann" uniqKey="Hagenah J" first="Johann" last="Hagenah">Johann Hagenah</name>
</author>
<author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The prerequisite for an earlier diagnosis of Parkinson's disease (PD) are markers that are both sensitive and specific for clinically definite PD and its prediagnosic phases. Promising candidates include enlarged hyperechogenicity of the substantia nigra (SN+) on transcranial sonography (TCS) and hyposmia. However, despite good sensitivity and specificity, both markers have yet failed to yield reliable predictions. We pursue the possibility of combined use in an ongoing population-based cohort. Subjects were recruited from 10,000 inhabitants of Luebeck/Germany aged 50 to 79 years and additional PD patients from our outpatient clinic. After neurological examination, 715 subjects were grouped into clinically definite PD (n = 106), possible prediagnostic PD (ppPD; n = 73), and a control group subdivided into healthy individuals (n = 283) and controls with diseases other than PD (n = 253). Subjects underwent TCS and smell testing. Sensitivity and specificity of SN+ and hyposmia were good for PD; however, positive predictive values (PPV) of both SN+ (5.2%) and olfaction (2.5%) were low. At least one positive/both positive markers were present in 33%/1% of healthy controls, 33%/2% of diseased controls, 62%/7% of ppPD, and 94%/51% of PD. When combining SN+ and hyposmia, PPV increased to 17.6%, with a sensitivity of 51% and a specificity of 98%. Both SN+ and hyposmia offer good enrichment towards PD and ppPD, are stable against other diseases, and the combination of markers highly increases specificity. However, if the combination of SN+ and hyposmia were used as criterion for PD diagnosis, almost half of clinically definite PD and more than 90% of ppPD would have been missed.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
</list>
<tree><noCountry><name sortKey="Al Khaled, Mohamed" sort="Al Khaled, Mohamed" uniqKey="Al Khaled M" first="Mohamed" last="Al-Khaled">Mohamed Al-Khaled</name>
<name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name>
<name sortKey="Graf, Julia" sort="Graf, Julia" uniqKey="Graf J" first="Julia" last="Graf">Julia Graf</name>
<name sortKey="Hagenah, Johann" sort="Hagenah, Johann" uniqKey="Hagenah J" first="Johann" last="Hagenah">Johann Hagenah</name>
<name sortKey="Hampf, Jennie" sort="Hampf, Jennie" uniqKey="Hampf J" first="Jennie" last="Hampf">Jennie Hampf</name>
<name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name>
<name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<name sortKey="Lorwin, Anne" sort="Lorwin, Anne" uniqKey="Lorwin A" first="Anne" last="Lorwin">Anne Lorwin</name>
<name sortKey="Piskol, Linda" sort="Piskol, Linda" uniqKey="Piskol L" first="Linda" last="Piskol">Linda Piskol</name>
<name sortKey="Schmidt, Alexander" sort="Schmidt, Alexander" uniqKey="Schmidt A" first="Alexander" last="Schmidt">Alexander Schmidt</name>
<name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name>
<name sortKey="Vollstedt, Eva Juliane" sort="Vollstedt, Eva Juliane" uniqKey="Vollstedt E" first="Eva-Juliane" last="Vollstedt">Eva-Juliane Vollstedt</name>
<name sortKey="Wolff, Simone" sort="Wolff, Simone" uniqKey="Wolff S" first="Simone" last="Wolff">Simone Wolff</name>
</noCountry>
<country name="Allemagne"><noRegion><name sortKey="Tunc, Sinem" sort="Tunc, Sinem" uniqKey="Tunc S" first="Sinem" last="Tunc">Sinem Tunc</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000344 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000344 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25546094
   |texte=   A population-based study on combined markers for early Parkinson's disease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25546094" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

A population-based study on combined markers for early Parkinson's disease.

A population-based study on combined markers for early Parkinson's disease.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.